Researchers: Anti-inflammatory drugs harm if given at the wrong time

We all know very well that long-term use of non-steroidal anti-inflammatory drugs carries great risks, but until now we didn’t realize that these were interfering with our body’s ability to heal wounds.

Researchers: Anti-inflammatory drugs harm if given at the wrong time

And since we take them not only for pain, but also for anti-inflammatory purposes, it’s not the best news. After all, as we learn from recent studies, non-steroidal anti-inflammatory drugs can slow down bone healing and repair processes, which is why they are not recommended even after orthopedic surgeries. Fortunately, it also turns out that there is a simple way to “get around” this problem, because the cause may simply be our diurnal rhythm – the researchers suggest that if we adjust the intake of drugs to it, everything will work properly.

In fact, it’s worth remembering that inflammation isn’t always bad for our bodies because, in fact, if the immune system is working effectively, inflammation plays a key role in healing and fighting infection. When the body is injured, inflammation is a fundamental step in the healing process that starts with getting rid of dead cells so that pathogens don’t interfere with the tissue repair process. – There are times when inflammation is destructive and there are times when it is constructive and important for healing. Therefore, many pharmaceutical companies are trying to create drugs that inhibit destruction without affecting the positive effects of inflammation, the researchers say.

The latest research began with a hypothesis inspired by what we already know about the relationship between circadian rhythms and immune system activity. Researchers set out to see if these natural cycles could be used to a patient’s advantage: – The destructive component of the diurnal cycle during bone fusion occurs during the day, when cells called osteoclasts destroy bone. In contrast, constructive cells called osteoblasts, which rebuild bone, are active at night. Limiting the use of nonsteroidal anti-inflammatory drugs to the mornings and giving painkillers at night may produce better results than giving anti-inflammatory drugs around the clock.

The researchers confirmed their theory by working on two groups of mice in which it was necessary to remodel a fractured tibia bone. One group was given non-steroidal anti-inflammatory drugs in the morning and evening, while the other group was only given the drugs in the morning, so they were supported by painkillers in the evening. It didn’t take long to see the results – the group with the morning dose of NSAIDs healed faster, and the mice also showed increased expression of more than 500 genes responsible for bone healing processes. According to the researchers: – It’s as if the drugs administered in the morning and evening are completely different.

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